Most metazoan organisms have evolved a mildly acidified and calcium diminished sorting hub in the early secretory pathway commonly referred to as the Endoplasmic Reticulum‐Golgi intermediate compartment (ERGIC). These membranous vesicular‐tubular clusters are found tightly juxtaposed to ER subdomains that are competent for the production of COPII‐coated transport carriers. In contrast to many unicellular systems, metazoan COPII carriers largely transit just a few hundred nanometers to the ERGIC, prior to COPI‐dependent transport on to the cis‐Golgi. The mechanisms underlying formation and (...) maintenance of ERGIC membranes are poorly defined. However, recent evidence suggests an important role for Trk‐fused gene (TFG) in regulating the integrity of the ER/ERGIC interface. Moreover, in the absence of cytoskeletal elements to scaffold tracks on which COPII carriers might move, TFG appears to promote anterograde cargo transport by locally tethering COPII carriers adjacent to ERGIC membranes. This action, regulated in part by the intrinsically disordered domain of TFG, provides sufficient time for COPII coat disassembly prior to heterotypic membrane fusion and cargo delivery to the ERGIC. -/- . (shrink)

'The problem of the twentieth-century is the problem of the color-line.' Originally published in 1903, The Souls of Black Folk is a classic study of race, culture, and education at the turn of the twentieth century. With its singular combination of essays, memoir, and fiction, this book vaulted W. E. B. Du Bois to the forefront of American political commentary and civil rights activism. The Souls of Black Folk is an impassioned, at times searing account of the situation of African (...) Americans in the United States. Du Bois makes a forceful case for the access of African Americans to higher education, memorably extols the achievements of black culture (above all the spirituals or 'sorrow songs'), and advances the provocative and influential argument that due to the inequalities and pressures of the 'race problem', African American identity is characterized by 'double consciousness'. This edition includes a valuable appendix of other writing by Du Bois, which sheds light on his attitudes and intentions. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more. (shrink)

A dialogue between a foreign philosopher and a powerful statesman outline Plato's reflections on the family, the status of women, property rights, and criminal law.

We describe in some detail how to build an infinite computing machine within a continuous Newtonian universe. The relevance of our construction to the Church-Turing thesis and the Platonist-Intuitionist debate about the nature of mathematics is also discussed.

The regular increase in the proportion of resolved feet in the iambic trimeters of Euripides' later plays was first commented upon in 1807 by J. Gottfried Hermann, who therefrom deduced the principle that the date of any play of Euripides could be directly determined from the frequency of its resolutions. This criterion he restated in several of his works in the following years, and when Elmsley objected that it was of uncertain value on account of the small number of plays (...) of certain date by which it might be verified, he replied with a strong defence of his case: he did not, however, develop his principle in detail or give figures in its support. The first scholar to publish the totals of trisyllabic feet in each play was Zirndorfer: relying largely on these, he produced a chronology of Euripides' dramatic composition in several respects superior to any predecessor's. His conclusions were questioned by C. F. W. Müller, who, while accepting Hermann's thesis as being in general correct, doubted its reliability for determining the exact period of a tragedy's composition. Consequently, although he gave the totals of trisyllabic feet en passant, Müller made no attempt to suggest dates. At almost the same time as Müller's treatise appeared, J. Rumpel published an article giving a full and detailed list of references to all trisyllabic feet in Euripides: from this evidence he divided the dramas into four age-groups, but did not go so far as to assign specific dates. (shrink)